在基础科学与医学中的蛋白质及其结构

Robert Huber

　　摘要： 近二十年来，蛋白质晶体学方法和仪器操作的快速发展，特别是与电镜结合时，可以确定大的、复杂的蛋白质结构。尽管这些结构不仅证明了蛋白质构造的无限多样性与适应性，还揭示了意想不到的关系。这些结构是了解蛋白结合特征、催化特性（化学）、光谱特性与电子转移特性（物理学）以及在生理系统中作用（生物学与医学）的基础。这些结构使得设计和研制靶蛋白的特异配基成为可能，为治疗干预与植物保护开辟了新的途径。

Title: Proteins and their structures in basic science and medicine

Robert Huber

　　Abstract: Protein crystallography experienced in the last twenty years a rapid development in methods and instrumentation, allowing the determination of very large and complex protein structures, particularly when combined with electron microscopy. These structures document an unlimited versatility and adaptability of the proteins′ architecture, but reveal also unexpected relationships. The structures are a basis for understanding their binding specificities and catalytic properties (chemistry), their spectral and electron transfer properties (physics), and their roles in physiological systems (biology and medicine). They allow design and development of specific ligands of target proteins opening novel ways for therapeutic intervention and for plant protection.